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Nancy Woehrle, Ph.D.

Nancy WoehrleAssociate Professor of Psychology
Director, Program in Neuroscience

Behavioral Neuroscience, Neuropsychiatric Disorder
Zimmerman Hall 201
(937) 327-7479
woehrlen@wittenberg.edu

Dr. Woehrle received her B.A. in Psychology from the University of Missouri-Columbia, and her Ph.D. in Neurobiology from the University of Chicago. Following completion of her Ph.D., she earned a postdoctoral fellowship in the Department of Psychiatry and Behavioral Neuroscience at the University of Chicago. Dr. Woehrle joined the Wittenberg faculty in 2012.

Dr. Woehrle has always been fascinated by the idea that human consciousness arises from biological substrates. She strives to understand the neural underpinnings of human psychological capacities, and is particularly interested in uncovering mechanisms of mental illness. Dr. Woehrle's research program aims to identify the neurobiological substrates that contribute to psychiatric disorders. Recent projects in her lab include investigations into novel medications for obsessive-compulsive disorder and autism, the mechanisms underlying the antidepressant effects of exercise, and the link between prenatal antidepressant exposure and autism risk.

Dr. Woehrle loves to teach neuroscience and psychology. She has earned the Omicron Delta Kappa Excellence in Teaching Award at Wittenberg University, and the Excellence in Teaching Award from the Southwestern Ohio Council for Higher Education. She aims to make her classroom a place where students can consider and discuss profound questions about human life and health with a grounding in the rigor of neuroscience.

Courses Taught:

  • PSYC 100S Understanding Psychology
  • PSYC 110N Physiological Psychology
  • PSYC 211N Sensation & Perception
  • PSYC 280N Psychopharmacology
  • PSYC 311B Behavioral Neuroscience
  • PSYC 400 Neuropsychiatric Disorder Research

Publications:

  • Bond, C.M, Johnson, J.C., Chaudhary, V., McCarthy, E.M., McWhorter M.L. & Woehrle, N.S. (2020). Perinatal fluoxetine exposure results in social deficits and reduced monoamine oxidase gene expression in mice. Brain Research 1727 (19), 30328-32. PMID: 31170382
  • Allen, E., Hughes, E., Anderson IV, C. & Woehrle, N.S. (2018). N-acetylcysteine blocks OCD-like behavior in mice. Behavioral Neuroscience 132 (4), 258-268. PMID: 29985009
  • Lawson, S.K., Gray, A.C. & Woehrle, N.S. (2016). Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice. Behavioural Brain Research 314, 52-64. PMID: 27439030
  • Cheng, L., Hattori, E. Nakajima, A., Woehrle, N.S., Opal, M.D., Zhang, C. Dulawa, S.C., Tang, Y., Gershon, E.S. & Liu, C. (2014). Expression of the G72/G30 gene in transgenic mice induces behavioral changes. Molecular Psychiatry 19(2), 175-83. PMID: 23337943
  • Woehrle, N.S. & Dulawa, S.C. (2014). Obsessive-Compulsive Disorder and Gilles de la Tourette’s Syndrome. In W.E. Crusio, F. Sluyter & S. Pietropaolo (Eds.), Behavioral Genetics of the Mouse (pp. 173-188). Cambridge, UK: Cambridge University Press.
  • Woehrle, N.S., Klenotich, S.J., Jamnia, N., Ho, E.V., & SC Dulawa (2013). Effects of chronic fluoxetine treatment on serotonin 1B receptor-induced deficits in delayed alternation. Psychopharmacology 227(3), 545-51. PMID: 23377022

Work published under previous name NA Shanahan:

  • Shanahan, N.A., Velez, L.P., Masten, V.A. & Dulawa, S.C. (2011). Essential role for orbitofrontal 5-HT1B receptors in OCD-like behavior and SRI response in mice. Biological Psychiatry 70(11),1039-1048. PMID: 21920503
  • Savic, D., Distler, M.G., Skoloff, G., Shanahan, N.A., Dulawa, S.C., Palmer, A.A. & Nobrega, M.A. (2011). Modulation of Tcf7l2 expression alters behavior in mice. PLoSOne 6(10), e26897. PMID: 22046400
  • Shanahan, N.A., Holick, K.A., Ansorge, M., Waeber, C., Gingrich, J.A., Hen, R. & Dulawa, S.C. (2009). Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biological Psychiatry 65(5), 401-408. PMID: 19013555

Abstracts:

[Wittenberg student co-authors denoted with brackets.]

  • [Bond, C. M.] & Woehrle, N.S. (2016) Autism-related behaviors in juvenile and adult mice following perinatal antidepressant exposure. Society for Neuroscience, San Diego, CA.
  • [Bond, C. M.] & Woehrle, N.S. (2016) Effects of perinatal antidepressant exposure on autism-like behaviors in mice. Midwestern Psychological Association, Chicago, IL.
  • [Lawson, S.K.] & Woehrle, N.S. (2014) Effects of oxytocin on serotonin 1B agonist-induced autism-related behavior in mice. Society for Neuroscience, Washington, D.C.
  • [Sroka, M.C.] & Woehrle, N.S. (2014). Evidence for the involvement of 5-HT1A receptors in the mechanisms underlying the antidepressant effects of exercise. Society for Biological Psychiatry, New York, NY.
  • [Carron, C.] & Woehrle, N.S. (2014) Effects of perinatal fluoxetine exposure on autism-related social behavior in mice. mGluRs, Crawfordsville, IN
  • [Gray, A.], [King, C.], [LaCagnin, M.], [Adams, M.] & Woehrle, N.S. (2014). Serotonin 1B agonist-induced autistic-like social interaction deficits in mice. Midwestern Psychological Association, Chicago, IL.

Work published under previous name NA Shanahan:

  • Shanahan, N.A., Klenotich, S.J., Jamnia, N. & Dulawa, S.C. (2012). Chronic fluoxetine treatment prevents serotonin 1B receptor-induced deficits in delayed alternation. Society for Neuroscience, New Orleans, LA, October.
  • Jamina, N., Shanahan, N.A., Klenotich, S.J. & Dulawa, S.C. (2011). Spatial working memory in a mouse model of obsessive-compulsive disorder. Midstates Consortium for Math and Science, St. Louis, MO.
  • Shanahan N.A., Velez, L.P., Masten, V.A. & SC Dulawa. (2011). Essential role for orbitofrontal 5-HT1B receptors in OCD-like behavior and SRI response in mice. American College of Neuropsychopharmacology, Waikoloa, HI.
  • Shanahan, N.A., Velez, L.P. & Dulawa, S.C. (2010). 5-HT1B-induced mouse model of OCD. Society for Neuroscience, San Diego, CA.
  • Klenotich, S.J., Dugad, P., Seiglie, M.P., Shanahan, N.A. & Dulawa, S.C. (2009). Fluoxetine treatment of Balb/cJ mice in an activity-based anorexia model. Society for Neuroscience, Chicago, IL.
  • Shanahan, N.A., Masten, V.L., Geyer, M.A., Dulawa, S.C. (2009). Serotonin reuptake inhibition blocks 5-HT1B-induced OCD-like behavior with a time-course that parallels human therapeutic response. Society for Neuroscience, Chicago, IL.
  • Wang, L. Shanahan, N.A. & Dulawa, S.C. (2008). Mechanisms underlying the behavioral response to chronic antidepressant treatment. Serotonin Club Meeting, Oxford, England.
  • Shanahan N.A. & Dulawa, S.C. (2008). Time-course and specificity for SRI treatment to reduce 5-HT1B-induced PPI deficits and perseverative hyperlocomotion. Society for Neuroscience, Washington D.C.
  • Shanahan, N.A. & Dulawa, S.C. (2007). Serotonin reuptake inhibitors specifically prevent serotonin 1B receptor agonist-induced reductions in PPI and perseverative behavior. Society for Neuroscience, San Diego, CA.            
  • Coulibaly, A.P., Shanahan, N.A., Shelat, P.B., Serfozo, P., Schachtman, T.R. & Simonyi, A. (20060. Region-specific induction of immediate early genes following inhibitory avoidance learning in rat brain.  Annual Biomedical Research Conference, Newark, DE.
  • Shanahan, N.A., Coulibaly, A.P., Dopheide, M., Shela, P. & Schachtman, T.R. (2005). Mechanisms by which metabotropic glutamate receptor 5 influences inhibitory avoidance learning. Midwest Psychological Association, Chicago, IL.
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